MCAT Biology Help » Biology » Systems Biology and Tissue Types » Immune and Lymphatic Systems » Lymphatic System » Lymphoid Organs

All of the following are parts of the lymphatic system, except the liver. The liver is considered to be primarily a part of the digestive system. 


In the lymph node, the B-cells are located in the cortex and the T-cells are located in the medulla. The stromal cells are structural cells that are not particular to an area of the lymph node. Dendritic cells will move through the lymph node to present antigens to the adaptive immune system cells.

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Primary lymphoid tissues refer to the tissues where lymphoid cells are generated, while secondary lymphoid tissues are the functional organs of the lymphatic system.

Lymphocytes are generated and developed in the bone marrow and thymus only. The spleen and lymph nodes are examples of secondary lymphatic organs.

Hypersensitivity reactions occur when body tissues are affected by an abnormal immune reaction. The result is damage to normal tissues and clinical illness. A peanut allergy is an example of a hypersensitivity reaction, but there are three additional broad classes.

One class involves the abnormal production or deposition of antibodies. Antibodies are B-cell derived molecules that normally adhere to pathogens, rendering them unable to continue an infection. When antibodies are produced against normal tissues, however, disease can result. Figure 1 depicts a schematic structure of an antibody.

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Antibodies can be divided into two peptide chains: heavy and light. Heavy chains form the backbone of the antibody, and are attached to light chains via covalent bonding. Each heavy and light chain is then further divided into constant and variable regions. Variable regions exhibit molecular variety, generating a unique chemical identity for each antibody. These unique patterns help guarantee that the body can produce antibodies to recognize many possible molecular patterns on invading pathogens.




Antibodies and antigens interact in secondary lymphoid tissue, such as the spleen. In addition to its role in promoting this interaction, what is the primary function of the spleen?